MiR-137 Deficiency Causes Anxiety-Like Behaviors in Mice
نویسندگان
چکیده
منابع مشابه
α5GABAA receptor deficiency causes autism‐like behaviors
The prevalence of autism spectrum disorders (ASDs), which affect over 1% of the population, has increased twofold in recent years. Reduced expression of GABAA receptors has been observed in postmortem brain tissue and neuroimaging of individuals with ASDs. We found that deletion of the gene for the α5 subunit of the GABAA receptor caused robust autism-like behaviors in mice, including reduced s...
متن کاملInsufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice.
L-histidine is one of the essential amino acids for humans, and it plays a critical role as a component of proteins. L-histidine is also important as a precursor of histamine. Brain histamine is synthesized from L-histidine in the presence of histidine decarboxylase, which is expressed in histamine neurons. In the present study, we aimed to elucidate the importance of dietary L-histidine as a p...
متن کاملCD226 deficiency improves cognitive functions and ameliorates anxiety‐like behaviors in mice
Background CD226 is a cell surface adhesion molecule expressed in the immune system and central nervous system. Although the role of CD226 in the function of immune cells has been well studied, there has been no report on the potential functional significance of CD226 in neural cells. Methods We investigated the role of CD226 on the cognitive function and behaviors using CD226 knockout (CD226...
متن کاملAnxiety - Like Behaviors in Mice Receptor Signaling Modulates
http://www.sciencemag.org/cgi/content/full/313/5786/536 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/313/5786/536/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http://w...
متن کاملPhf8 loss confers resistance to depression-like and anxiety-like behaviors in mice
PHF8 is a histone demethylase with specificity for repressive modifications. While mutations of PHF8 have been associated with cognitive defects and cleft lip/palate, its role in mammalian development and physiology remains unexplored. Here, we have generated a Phf8 knockout allele in mice to examine the consequences of Phf8 loss for development and behaviour. Phf8 deficient mice neither displa...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2019
ISSN: 1662-5099
DOI: 10.3389/fnmol.2019.00260